Organizer;Center for Life Sciences, National Laboratory Astana, Nazarbayev University Date;20-21 October, 2022 Venue;Nazarbayev University Website;link=http://nla.nu.edu.kz.tilda.ws/page29902276.html Organizing Committee;Chairman: Dos Sarbassov, Director General, National Laboratory Astana, Nazarbayev University Members of organizing committee;Dos Sarbassov, Massimo Pignatelli, Almagul Kushugulova, Farkhad Olzhayev, Sholpan Askarova, Ainur Akilzhanova, Ulykbek Kairov, Yuliya Safarova Coordinators; Yuliya Safarova: тел: +7 (7172) 70 65 11, email: yantsen@nu.edu.kz Science Office: тел: +7 (7172) 70 62 93, email: nazira.moldakimova@nu.edu.kz,

Time;Program item;Speaker;Venue

08:00 - 09:00;Registration; ;Block S1, 2d floor, NLA; 09:00 - 10:05;OPENING SESSION;Dos Sarbasssov, Professor, General Director of National Laboratory Astana;Conference Hall, 2d floor, NLA 09:00 - 09:15;Welcome & Introduction;Dos Sarbassov, General Director of National Laboratory Astana; ; ;Welcome note;Zhaxybay Zhumadilov, Professor of Praactice, School of Medicine, Nazarbayev University; ; ;Welcome note;Takatsugu Mihara, ISTC, Kazakhstan 09:15 - 09:40;Experiences in risk communication for recovery of the community in Fukushima after the nuclear disaster;Professor Noboru Takamura, Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University;On-line 09:40 - 10:05;Molecular Dissection of Alzheimer’s Disease;Professor Joseph H. Lee, Columbia University, USA;On-line 10:05 - 10:10;Group photo of conference participants; ;Sky Walk, M floor 10:10 - 10:30;Coffee Break; ;Sky Walk, M floor

Time;Program item;Speaker;Venue

10:30 - 10:50;The new effects of radioactive microparticles for rats and mice and our future plan;Professor Masaharu Hoshi, Professor Emeritus at Hiroshima University, Tokyo, Japan;On-line 10:50 - 11:10;Single neonatal irradiation induces long-term morphological and gene expression changes in the thyroid of rats - a possible mechanism of thyroid carcinogenesis by childhood radiation;Professor Nariaki Fujimoto, Associate Professor, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan;On-line 11:10 - 11:30;Population-based human genetics research in resource-poor environments;Professor Joseph Terwilliger, Professor of Neurobiology, Columbia University Medical Center, USA ;On-line 11:30 - 11:50;Genome wide SNPs genotyping in cohort of individuals affected by organochlorine pesticides to define the most health impact;Dr Leyla Djansugurova, General Director of the RSE "Institute of Genetics and Physiology";On-line 11:50 - 12:10;Regulation of clinical trials of medicines in the Republic of Kazakhstan and the EAEU;Dr Shynar Baidullaeva, Doctor of Biological Sciences, Head of the Department of Medicines, National Centre for Expertise of Drugs, Medical Products and Medical Equipment;On-line 12:10 - 12:30;Genome-Wide Methods of Analysis: A Lab Perspective;Dr. Oksana Ryzhkova, Head of Shared Resource Centre (SRC) at “Genom, FSBI “RCMG”, Russia;On-line 12:30 - 12:40;Actual solutions from Illumina on the example of a new exome panel;Dr Svetlana Bulanenkova , ООО «Albiogen», Russia;On-line 12:40 - 13:00;Pharmacovigilance and post-marketing research;Miyanova Gulraykhan, Expert of the Department of Pharmacovigilance, National Centre for Expertise of Drugs, Medical Products and Medical Equipment; ; 13:00 - 13:20;Requirements for the quality of investigational medicinal products;Dr Bagila Nurmagambetova, Head of the Department of Expertise of Clinical Trials Materials, National Centre for Expertise of Drugs, Medical Products and Medical Equipment, Kazakhstan; ; 13:20 - 14:00;BUFFET LUNCH; ;Sky Walk, M floor 14:00 - 14:30;POSTER SESSION; ;Sky Walk, M floor

Time;Program item;Speaker;Venue

14:30 - 14:50;Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution;Dr Andrei Zinovyev, Senior Researcher, Scientific Coordinator of the Department of Bioinformatics and Computational Systems Biology of Cancer, Institute Curie, Paris, France;On-line 14:50 - 15:10;Risk factors for overweight and obesity in Kazakh elderly population;Dr Adil Supiyev, Karolinska Institut, Sweden;On-line 15:10 - 15:30;Repeatome dynamics in plant genome evolution;Dr Alexander Belyayev, Head of the Laboratory of Molecular Cytogenetics and Karyology Institute of Botany of the ASCR, Czech Republic;On-line 15:30 - 15:50;Live until 120: Myth or Reality?;Dr Talgat Nurgozhin, Corresponding Member of the National Academy of Sciences of the Republic of Kazakhstan, Chairman of the Department of Biomedical Sciences of the National Academy of Sciences of the Republic of Kazakhstan; ; 15:50 - 16:10;Development of the biomedical research market in the Republic of Kazakhstan: problems and solutions;Dr Vitaly Koikov, Vice-Rector for Research, MUA, Kazakhstan; ; 16:10 - 16:30;Epidemiological study of the impact of socio-economic, psychosocial and behavioral factors on the health of the population of the Republic of Kazakhstan, including major chronic non-communicable diseases and COVID-19;Dr Timur Saliev, Head of the Research Institute of FM Atchabarov, Almaty, Kazakhstan 16:30 - 16:50;A personalized approach to optimizing lipid-lowering pharmacotherapy with stable stenocardia in Kazakh population;Dr Altyn Nurpeissova, Head of Clinical Pharm Department, Medical centre hospital of president’s affairs administration of the Republic of Kazakhstan; ; 16:50 - 17:10;Precision oncology in Czech Republic. An expert perspective on NGS use in cancer care in Central Europe;Professor Ondřej Slabý, Professor Of Medical Biochemistry, Czech Republic;On-line 17:10 - 17:30;Antibiotic Resistance and Virulence of Klebsiella pneumoniae in Georgia;Dr David Tsereteli, M.D., Ph.D. Chief Specialist, Department of Communicable Disease, National Center for Disease Control and Public Health, Tbilisi, Georgia;On-line 17:30 - 17:50;First steps into Kyrgyz population Genomics;Dr NurlanTorokeldiev, Evolutionand Population geneticist, Khorog Campus, University of CentralAsia, Tajikistan; ; 17:50 - 18:00;New approaches in molecular diagnostics: the present and future of personalised healthcare;Dr. Alexey Anikaev - Customer Solution Manager, Genomics Russia & CIS, QIAGEN Russia, Moscow; ; 18:00 - 18:20;Nuclear medicine: present and future;Professor Aigul Saduakasova, Head of the Department of Nuclear Medicine, Medical centre hospital of president’s affairs administration of the Republic of Kazakhstan; ; 10 min;POSTER AWARD/PHOTO ;Chairs Closing Comments; ;BUFFET DINNER; ;Skywalk, M floor

Time;Program item;Speaker;

09:30 - 10:00;Morning Coffee; ; 10:00 - 10:10;Welcome note; ; 10:10 - 10:30;Development of a therapy for the treatment of pancreatic cancer through a combination of oxidative drugs suppressing KRAS mutant cancer cells;Dr Dos Sarbassov, General Director of National Laboratory Astana; 10:30 - 10:50;Study of new covalent DNA modifications and their role in DNA repair and chromatin organization;Dr Bakhit Matkarimov, Leading Reseacher, Laboratory of biosensors and bioinstruments, National Laboratory Astana, Kazakhstan; ; 10:50 - 11:10;Towards personalized medicine: inhibition of Bcl-xL induces apoptosis exclusively during and after mitotic arrest;Dr Ivan Vorobiev, Head of the Laboratory of biophotonics imaging, National Laboratory Astana, Kazakhstan 11:10 - 11:30;The study of the formation of stable secondary structures of DNA, in relation to DNA technologies;Dr Ruslan Kalendar, Leading Reseacher, Laboratory of bioinformatics and systems biology, National Laboratory Astana, Kazakhstan; 11:30 - 11:50;Determination of microbiome and genomic biomarkers of rheumatoid arthritis in Kazakhstani population;Dr Argul Issilbayeva, Reseacher, Laboratory of human microbiome and longevity, National Laboratory Astana, Kazakhstan; 11:50 - 12:10;Development of a software package for processing microscopic images of focal contacts;Dr Arshat Urazbayev, Senior Reseacher, Laboratory of computational materials science for energy application, National Laboratory Astana, Kazakhstan; 12:10 - 12:30;Targeting the small GTPase Cdc42 in aging adipose mesenchymal stem cells to increase the effectiveness of cell therapy for bone regeneration;Dr Bauyrzhan Umbayev, Leading Researcher, Laboratory of bioengineering and regenerative medicine, National Laboratory Astana, Kazakhstan 12:30 - 12:50;Circulating adiponectin levels, expression of adiponectin receptors, and methylation of adiponectin gene promoter in relation to Alzheimer’s disease;Dr Sholpan Askarova, Head of the Laboratory of bioengineering and regenerative medicine, National Laboratory Astana, Kazakhstan 12:50 - 14:00;LUNCH; ;

15:00 - 17:00;Presentations of the upcoming projects; ;