Laboratory of Molecular Oncology is aimed at future translation of fundamental discoveries about cancer mechanisms into the development of potential prognostic markers and therapeutic strategies. Research in the field of molecular oncology contributes to the understanding of the chemical, molecular, biochemical, cellular basis of cancer and tumor progression, including signal transmission processes, the role of energy and metabolism in cancer pathology, DNA damage, drug resistance, etc.
RESEARCH AREAS
Study of the mechanisms underlying cancer, for a deep understanding of the biology of tumors,
Development and optimization of new anticancer therapy,
Development of new solutions in CAR immunotherapy against solid tumors,
Conducting preclinical and clinical trials,
Prospects for the translation of new targeted methods of diagnosis and treatment of oncological pathologies into the clinic,
Development and optimization of new anticancer therapy,
Development of new solutions in CAR immunotherapy against solid tumors,
Conducting preclinical and clinical trials,
Prospects for the translation of new targeted methods of diagnosis and treatment of oncological pathologies into the clinic,
Prospects for the implementation of CRISPR/Cas9 technology, three-dimensional cultivation of organoids, including samples from patients with cancer.
MEMBERS
- Nikolai BarlevProfessor and Laboratory Head
- Dos SarbassovProfessor
and NLA General Director - Dinara Begimbetova, Ph.DA/Professor
and Leading Reseacher - Dina RakhmashAssistant Researcher
- Aleksei PetukhovAssistant Researcher
EQUIPMENT
The CELENA® X High Content Imaging System
An integrated imaging system designed for rapid, high content image acquisition and analysis. Customizable imaging protocols, image-based and laser autofocusing modules, and a motorized XYZ stage simplify well plate imaging and slide scanning. The integrated CELENA® X Cell Analyzer software processes images and data for quantitative analysis. Research methods: 4-channel fluorescence, brightfield, phase contrast, colour brightfield.
BioTek Cytation 5 Cell Imaging Multimode Reader
Combines automated microscopy and conventional microplate detection in a configurable, upgradable platform. The microscopy module offers up to 60x magnification in fluorescence, brightfield, high contrast brightfield, color brightfield, and phase contrast to address many applications and workflows.
Olympus BX53, Japan
Trinocular transmitted light microscope complete with fluorescence, color digital camera and digital monochrome camera with monochrome capability, software for karyotyping (Vision), FISH analysis and DNA comet analysis (TriTek CometScorePro).