Bioinformatics and Systems Biology Laboratory
Laboratory of Bioinformatics and Systems Biology is focused on development of new approaches of ICA application for analysis and interpretation of tumor heterogeneity, on the study of gene expression and genomic variants in cancer/normal tissues, on analysis of whole genomes/exomes of Kazakh individuals and identification of Kazakh specific genomic variants with developing national genomic reference database, on the study of differential expression in plants in different states and parts, genome organization and genetic variants of drug-resistant M.tuberculosis strains circulating in Kazakhstan, on development of bioinformatics tools implementing a machine learning approaches as applied to DNA detection and amplification technologies as well as development of novel bioinformatics tools and databases.
| MAIN RESEARCH AREAS Bioinformatics analysis of high-throughput genomic data from the next-generation sequencing platforms (Illumina NovaSeq/HiSeq2000/MiSeq, Roche 454) and third generation sequencing platform (Oxford nanopore) Bioinformatics analysis and meta-analysis of tumor transcriptomes from high-throughput microarray platforms (Affymetrix/Illumina) Bioinformatics analysis of cancer transcriptome and gene expression data from next-generation sequencing platform Illumina NovaSeq/HiSeq2000 / MiSeq Development of bioinformatics tools that implement machine learning approaches applied to DNA detection and amplification technologies for solving complex problems, including the development of PCR primers, probes and microarrays, as well as targeted sequencing Development of new integrative bioinformatics approaches and methods for analysis of human whole transcriptomes and whole genomes Development of bioinformatics facility, biological databases, bioinformatics methods for analysis of multidimensional biomedical data Primers design and optimization of PCR pipelines and amplification |
MEMBERS
- Ulykbek Kairov, PhDLeading Researcher and Lab Head
- Ruslan Kalendar, PhDProfessor and Leading Researcher
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Asset Daniyarov
Researcher -
Askhat Molkenov, PhD
Researcher -
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Rakhimbek Bektayev
Junior Researcher -
Kamila Temirkhanova
Research Assistant -
Sultan Makhmetov
Research Assistant
EQUIPMENT
Server Dell T430 (2x Intel Xeon (12 Cores), 64 Gb RAM, 8 Tb RAID, Windows Server)
Medium-performance server on Windows platform for developing Windows-based bioinformatics methods and Matlab codes application.
Small bioinformatics cluster Dell PowerEdge Cluster (64 x Cores AMD Opteron, 128 Gb RAM, 20 Tb RAID)
High-performance server capable to perform tasks on analysis of small sample size next-generation sequencing data (human whole-genome, whole-exomes, whole transcriptomes analysis, up to 10 samples simultaneously).
Server HP Z800 (2х Intel Xeon (16 Cores), 48 Gb RAM)
Medium-performance server for performing bioinformatics analysis of viral and bacterial genomes
Synology Storage System (50 Tb Raid)
Archiving server for massive storage and biomedical data encryption