WORK WITH NLA
Let's collaborate to create a better world
Our business partnerships with other companies, academic institutions, and research organizations play a critical role in achieving our research goals. By working together, we can leverage each other's strengths, resources, and expertise to conduct high-quality research and implement their results for the benefit of society.
We are in constant search and strive to maintain strong relationships with our partners who can help us expand our research capabilities and bring even greater benefits. Based on our experience and resources, we are able to offer tailored services to private companies, academic institutions, as well as government agencies to help them achieve their objectives effectively and efficiently.
We are in constant search and strive to maintain strong relationships with our partners who can help us expand our research capabilities and bring even greater benefits. Based on our experience and resources, we are able to offer tailored services to private companies, academic institutions, as well as government agencies to help them achieve their objectives effectively and efficiently.
PARTNERSHIP OFFERINGS
PRIVATE INDUSTRIES
HEALTH CENTERS
ACADEMIC AND RESEARCH INSTITUTES
GOVERNMENT AGENCIES
LEGAL ENTITIES AND INDIVIDUALS
OUR COLLABORATIONS
NLA is a leading research institution based on innovations and collaboration opportunities with local and foreign research centers. This is achieved through the laboratory's technology transfer, commercialization and partnership efforts, which are focused on scientific advances in areas such as health, energy, environment and security.
We recognize the value of partnering with various entities from innovative startups, industries, to government agencies and research centers/universities. Collaborating with them extends opportunities and allows us to achieve goals most effectively.
We eager to join forces with partners to stimulate innovation and progress for the benefit of society.
We recognize the value of partnering with various entities from innovative startups, industries, to government agencies and research centers/universities. Collaborating with them extends opportunities and allows us to achieve goals most effectively.
We eager to join forces with partners to stimulate innovation and progress for the benefit of society.
BIOLOGY
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RENEWABLE ENERGY
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MEDICINE
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ADVANCED MATERIALS
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Research Possibilities
- Bioinformatics analysis of human whole-genomes/exomes from high-throughput next-generation sequencing platforms (Illumina/Roche/SOLiD/IonTorrent)
- Bioinformatics analysis of human cancer transcriptomes from high-throughput genomic platforms (microarrays, NGS - Illumina/Affymetrix).
- Bioinformatics analysis of viral and bacterial genomes.
- Development of new bioinformatics methods and approaches and databases for analysis and visualization of multidimensional biomedical data from high-throughput genomic platforms.
- Training and internships for young Kazakhstani researchers as well as consulting in bioinformatics for different research centers from Kazakhstan.
- More than 100 bioinformatics methods , tools and pipelines have been implemented and installed
- Active research collaboration with leading international bioinformatics groups and centers in the field of bioinformatics, genomics and systems biology;
Main services
- Bioinformatics analysis of viral and bacterial whole-genomes
- Bioinformatics analysis of whole-transcriptomes
- Bioinformatics analysis of whole-genomes/exomes and GWAS data
- Primer design and optimization
LBRM_Our expertise
- Analysis of cell proliferation and cell cycle
- Electrochemiluminescence immunoassay method for proteins detection in cell cultures, tissues, and other biological samples
- Production of luciferase-expressing cell lines
- Quantitative fluorescent microscopy
- In-vivo fluorescent and bioluminescent tomography
- In-vivo micro-CT
- In-vivo rat model of estrogen-depended osteoporosis
- In-vivo rat model of bone fracture
- In-vivo rat model of ischemic stroke
- Gel electrophoresis, Western blot, PCR
- Quantitative spectrophotometry
Analisis of data from high-throughput genomic platforms
- Statistical analysis of the data from high-throughput genomic platforms(next-generation sequencing, microarrays);
- Development and application of methodologies for meta-analysis;
- Application of mathematical methods for analysis of high-throughput data;
- Implementation, testing and adjustment different bioinformatics protocols and software for data analysis.
Computational Systems Biology of Cancer
- Network and complex analysis of cancer signalling pathways;
- Development of maps and models of cancer signaling pathways using systems biology standards, programming languages, and software (SBML, SBGN, CellDesigner).
Computational Functional Genomics
- Functional annotation and analysis of validated lists of genes;
- Interpretation and functional characterization of genomic data;
- Visualization of multi-dimensional genomic data.
Applied Bioinformatics
- Development of databases and software;
- Application of cloud computing;
- Work with high-performance computing clusters;
- Storing and managing of genomic data.
Human microbiome laboratory is performing:
- the studies on human metagenome in the Republic of Kazakhstan;
- development of functional foods and drugs to correct microflora, as well as developing the regulatory standard documentation;
- creating biobank samples of human microflora;
- the provision of practical healthcare, industrial and commercial enterprises by the analysis of the biological material using of advanced technologies in biomedical science;
- the creation of public associations: Kazakhstan Association of Human microbiome research.
Microbiome Lab Main Services
- Isolation of DNA from pure cultures of bacteria and fungi.
- Isolation of DNA of microorganisms from human biological fluids.
- Extraction of DNA from the stool
- Isolation of DNA from blood
- 16S rRNA sequencing of single bacteria
- ITS sequencing, for mushrooms
- Microbiome analysis, alpha, beta diversity, LDA (LefSe)
- SNP genotyping by the classical method
- SNP Genotyping Real-time PCR
- 16S rRNA / ITS microbiome sequencing
- Isolation of pure cultures of microorganisms.
- Determination of QMAFAnM (total microbial number) - the number of mesophilic aerobic and facultative anaerobic microorganisms.
- Determination of antibiotic susceptibility / resistance of bacteria
- Determination of antigenotoxic action
- Antioxidant activity
- Antimicrobial activity
- Adhesive activity of bacteria
- Determination of Coli-titer, Coli-index
- Physical and chemical research of milk and dairy products
- Microbiological examination of milk and dairy products, probiotics.
- Laboratory drying of bacteria
- Production of pilot batches of microbial preparations (up to 10 liters)
- Screening bacteria for probiotic properties
- Conducting preclinical studies on the safety of new substances and drugs
- Study of the toxicity of nanomaterials
- Study of the pharmacokinetics of new drugs
- Study of the effectiveness of antimicrobial and antifungal drugs
- Study of the effectiveness of probiotics and prebiotics on the model of intestinal dysbiosis in laboratory animals
- Study of antitumor activity in mouse models
- Bioequivalence research of medicines
- Pharmacoeconomic research
PATENTS_LBRM
- Patent for the invention of the Republic of Kazakhstan №34466 from 11.09.2020 "APPLICATION OF PLANT SUBSTANCE ISOLATED FROM THE ROOTS OF GERMIN KERMEK WITH NEUROPROTECTIVE EFFECT".
- Patent of the Republic of Kazakhstan for a utility model №5209 from 24.07.2020 "POLYMER-PROTEIN URICASE CONJUGATE WITH HYPOURICEMIC ACTION".
- Patent for the invention of the Republic of Kazakhstan №34147 from 02.07.2020 "METHOD OF TREATING BONE FRACTURE IN OSTEOPOROSIS AND SIMILAR PATHOLOGIES OF BONE TISSUE IN EXPERIMENT".
- Copyright certificate of the Republic of Kazakhstan №6088 from 10.25.2019 «METHOD OF REGULATING SECRETARY PHENOTYPE RELATED TO AGING (Anti-SASP THERAPY) OF SKIN USING SMALL MOLECULES TO ACTIVATE THE REGENERATIVE POTENTIAL OF SKIN IN AGING».
- Patent for the invention of the Republic of Kazakhstan №33564 from 04.05.2019 "WOUND COATING BASED ON POLOXAMER 407 AND AMNIOTHIC MEMBRANE EXTRACT".
- Copyright certificate of the Republic of Kazakhstan №2078 from 03.01.2019 «QUALITY MANAGEMENT OF COLONOSCOPY IN COLORECTAL CANCER SCREENING».
- Copyright certificate of the Republic of Kazakhstan №1776 from 02.15.2019 «METHOD FOR INFLAMMATION INDUCED CANCER DETECTION IN MOUSE MODEL USING DIFFUSION FLUORESCENT TOMOGRAPHY».
- Copyright certificate of the Republic of Kazakhstan №1748 from 02.13.2019 «EXPERIMENTAL MODEL OF FOCAL ISCHEMIC BRAIN DAMAGE BY OCCLUSION OF THE MIDDLE CEREBRAL ARTERY».
- Patent of the Republic of Kazakhstan for a utility model №1287 on 07.15.2015, "DEVICE FOR IN VITRO GAS EXCHANGE FOR TREATMENT OF SEVERE RESPIRATORY FAILURE IN CHILDREN".