Organizer;Center for Life Sciences, National Laboratory Astana, Nazarbayev University Date;20-21 October, 2022 Venue;Nazarbayev University Website;link=http://nla.nu.edu.kz.tilda.ws/ Organizing Committee;Chairman: Dos Sarbassov, Director General, National Laboratory Astana, Nazarbayev University Members of organizing committee;Dos Sarbassov, Massimo Pignatelli, Takatsugu Mihara, Almagul Kushugulova, Farkhad Olzhayev, Sholpan Askarova, Ainur Akilzhanova, Ulykbek Kairov, Yuliya Safarova Coordinators; Yuliya Safarova: тел: +7 (7172) 70 65 11, email: yantsen@nu.edu.kz Science Office: тел: +7 (7172) 70 62 93, email: nazira.moldakimova@nu.edu.kz,

Time;Program item;Speaker;Venue

08:30 - 09:00;Registration; ;Conference Hall, NLA; 09:00 - 10:20;OPENING SESSION;Dos Sarbasssov, Professor, Director General of National Laboratory Astana;NLA, Nazarbayev University 09:00 - 09:05;Welcome & Introduction;Dos Sarbassov, Director General of National Laboratory Astana; ; 09:15 - 09:20;Welcome note;Zhaxybay Zhumadilov, former Director General; ; 09:20 - 09:25;Welcome note;Takatsugu Mihara, МНТЦ, Kazakhstan 09:25 - 09:50;Experiences in risk communication for recovery of the community in Fukushima after the nuclear disaster;Professor Noboru Takamura, Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University;On-line 09:50 - 10:15; ;Professor Joseph H. Lee, Columbia University, USA;On-line 10:15 - 10:20;Group photo of conference participants; ;Sky Walk 10:20 - 10:40;Coffee Break; ;Sky Walk

Time;Program item;Speaker;Venue

08:30 - 09:00;Registration; ;Conference Hall, NLA; 09:00 - 10:20;OPENING SESSION;Dos Sarbasssov, Professor, Director General of National Laboratory Astana;NLA, Nazarbayev University 09:00 - 09:05;Welcome & Introduction;Dos Sarbassov, Director General of National Laboratory Astana; ; 09:05 - 09:10;Welcome note;Massimo Pignatelli, Dean of the School of Medicine, Nazarbayev University; ; 09:10 - 09:15;Welcome note;Ilesanmi Adesida, Provost of the Nazarbayev University; ; 09:15 - 09:20;Welcome note;Zhaxybay Zhumadilov, former Director General; ; 09:20 - 09:25;Welcome note;Takatsugu Mihara, МНТЦ, Kazakhstan 09:25 - 09:50;Experiences in risk communication for recovery of the community in Fukushima after the nuclear disaster;Professor Noboru Takamura, Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University;On-line 09:50 - 10:15;Report;Professor Joseph H. Lee, Columbia University, USA;On-line 10:15 - 10:20;Group photo of conference participants; ;Sky Walk 10:20 - 10:40;Coffee Break; ;Sky Walk

Time;Program item;Speaker;Venue

10:40 - 11:00;Report;Professor Masahira Hattori, Professor Emeritus at The University of Tokyo, Japan;On-line 11:00 - 11:20;Report;Professor Nariaki Fujimoto, Associate Professor, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan;On-line 11:20 - 11:40;Report;Professor Joseph Terwilliger, Columbia University Medical Center, USA;On-line 11:40 - 12:00;Report;Dr Leyla Djansugurova, General Director of the RSE "Institute of Genetics and Physiology";On-line 12:00 - 12:20;Report - Regulation of clinical trials of medicines in the Republic of Kazakhstan and the EAEU;Dr Shynar Baidullaeva, Doctor of Biological Sciences, Head of the Department of Medicines, National Centre for Expertise of Drugs, Medical Products and Medical Equipment;On-line 12:20 - 12:40;Report - Pharmacovigilance and post-marketing research;Miyanova Gulraykhan, Expert of the Department of Pharmacovigilance, National Centre for Expertise of Drugs, Medical Products and Medical Equipment; ; 12:40 - 13:00;Report - Requirements for the quality of investigational medicinal products;Natalia Loseva, Expert of the Department of Expertise of Clinical Trials Materials, National Centre for Expertise of Drugs, Medical Products and Medical Equipment; 13:00 - 14:00;BUFFET LUNCH; ;

Time;Program item;Speaker;Venue

14:00 - 14:30;POSTER SESSION; ;Sky Walk 14:30 - 14:40;Welcome note; ; 14:40 - 15:00;Report;Dr Giullietta Rau, PhD, Senior Researcher, ISM-CNR Istituto di Struttura della Materia Consiglio Nazionale delle RicercheRome, Italy;On-line 15:00 - 15:20;Report;Dr Andrei Zinoviev, Scientific Coordinator of the Department of Bioinformatics and Computational Systems Biology of Cancer, Institute Curie, Paris, France / Ecole des Mines ParisTech, Fontainebleau, France;On-line 15:20 - 15:40;Report;Dr Adil Supiyev, Karolinska Institut, Sweden;On-line 15:40 - 16:00;Report - Repeatome dynamics in plant genome evolution;Dr Alexander Belyalov, Head of the Laboratory of Molecular Cytogenetics and Karyology Institute of Botany of the ASCR, Czech Republic;On-line 16:00 - 16:20;Report;Dr Talgat Nurgozhin; 16:20 - 16:40;Report;Dr Vitaly Koikov, Vice-Rector for Research, MUA; 16:40 - 17:00;Report;Dr Timur Saliev, PhD, head of the Research Institute of FM them. Atchabarova 17:00 - 17:20;Report;Dr Raushan Karabayeva, Deputy director for medical work, Medical centre hospital of president’s affairs administration of the Republic of Kazakhstan 17:20 - 17:40;Report;Dr Aigul Sadvakasova, Head of the Department of Nuclear Medicine, Medical centre hospital of president’s affairs administration of the Republic of Kazakhstan 17:40 - 18:00;Report;Dr David Tsereteli, M.D., Ph.D. Chief Specialist, Department of Communicable Disease, National Center for Disease Control and Public Health, Tbilisi, Georgia;On-line 18:00 - 18:20;Report;Dr NurlanTorokeldiev, Kyrgystan 10 min;Presentation from Sponsor 10 min;POSTER AWARD/PHOTO ;Chairs Closing Comments; ;BUFFET DINNER

Time;Program item;Speaker;

09:30 - 10:00;Morning Coffee; ; 10:00 - 10:10;Welcome note; ; 10:10 - 10:30;Report - AP08857553 Development of a therapy for the treatment of pancreatic cancer through a combination of oxidative drugs suppressing KRAS mutant cancer cells;Dr Dos Sarbassov; 10:30 - 10:50;Report - AP08856264 The role of the Cdc42 protein in the regulation of mesenchymal stem cell aging;Dr Bauyrzhan Umbayev; 10:50 - 11:10;Report - AP08857554 Towards Personalized Medicine: Analysis of the Combined Efficacy of Antimitotic Drugs and Inhibitors of the Bcl-2 Protein Family in Complex Chemotherapy;Dr Ivan Vorobiev 11:10 - 11:30;Report - AP08855353 The study of the formation of stable secondary structures of DNA, in relation to DNA technologies;Dr Ruslan Kalendar; 11:30 - 11:50;Report - АР08052703 Determination of microbiome and genomic biomarkers of rheumatoid arthritis in Kazakhstani population;Dr Assel Meiramova; 11:50 - 12:10;Report - АР08053387 Development of a software package for processing microscopic images of focal contacts;Dr Arshat Urazbayev; 12:10 - 12:20;Report - 091019CRP2113 Targeting the small GTPase Cdc42 in aging adipose mesenchymal stem cells to increase the effectiveness of cell therapy for bone regeneration;Dr Bauyrzhan Umbayev 12:20 - 12:40;Report - 091019CRP2112 The study of the activity of peripheral blood monocytes and the expression of adiponectin receptors in association with the content of adiponectin in plasma in patients diagnosed with Alzheimer's disease;Dr Sholpan Askarova 12:40 - 13:00;Report - 091019CRP2111 Study of new covalent DNA modifications and their role in DNA repair and chromatin organization;Dr Bakhit Matkarimov 13:00 - 14:00;LUNCH; ;

15:00 - 17:00;Presentations of the upcoming projects; ;