Role of the gut microbiome in inflammatory bowel disease (IBD) pathogenesis
2025-05-16 10:24
Project goal: The goal of this project is to identify promising microbiome markers of inflammatory bowel disease (IBD) for screening, prognosis, and early diagnosis. The working hypothesis of the project is that colonization by opportunistic microorganisms in the gut is caused by an imbalance in microbial homeostasis, which increases the likelihood of a host immune response and contributes to the development of IBD. In turn, the gut microbiome is shaped by routine interpersonal contacts, with most bacteria being directly transmitted between community members. Therefore, in our study, the control group consists of household members of patients diagnosed with IBD
Project description: Significant triggers for the development of inflammatory bowel diseases include negative environmental influences and internal imbalance. A growing number of studies show that changes in the composition and function of the microbiota correlate with disease progression. For this reason, understanding the pathophysiology of these diseases and developing diagnostic and therapeutic strategies for IBD should be based on microbiome research. The project aims to establish a conceptual foundation for understanding the etiopathogenesis of IBD and for future development of screening, prognostic, diagnostic, preventive, and therapeutic tools based on gut microbiome studies
Project facilitators: PI: Laura Chulenbayeva Almagul Kushugulova Samat Kozhakhmetov Argul Issilbayeva Nurislam Mukhanbetzhanov Madiyar Nurgaziyev Zharkyn Jarmukhanov Symbat Seidulla
Realisation period: 2023-2025
Expected results: As a result of the project’s objectives, the following outcomes will be achieved: Patients diagnosed with IBD and a control group will be recruited. A total of 143 stool samples from IBD patients and 143 stool samples from the control group will be collected for gut microbiome analysis. DNA extraction will be performed, followed by microbiome analysis. The gut microbiome will be analyzed using 16S rRNA gene sequencing to determine its taxonomic composition, and the obtained results will be used for further statistical and correlation analysis. Statistical analysis will be conducted to identify trends, relationships, and patterns associated with the disease, expanding our understanding of IBD and guiding clinical management. 1) project results will be published in international peer-reviewed scientific journals. The project's success will be evaluated based on the publication of articles according to the requirements of the competition documentation: - At least 3 (three) articles and/or reviews in peer-reviewed scientific journals indexed in the Science Citation Index Expanded (SCIE) of Web of Science and/or with a CiteScore percentile of at least 35 in Scopus. - Or at least 2 (two) articles and/or reviews in peer-reviewed scientific journals indexed in SCIE (Web of Science) and/or with a CiteScore percentile of at least 35 in Scopus, plus at least 1 (one) patent included in the Derwent Innovations Index (Web of Science, Clarivate Analytics). - Additionally, at least 1 (one) article or review in a peer-reviewed international or domestic journal recommended by CQASHE (Committee for Quality Assurance in Science and Higher Education). - Or at least 2 (two) articles and/or reviews in peer-reviewed scientific journals indexed in SCIE (Web of Science) and included in the 1st (first) and/or 2nd (second) quartile by impact factor in Web of Science and/or with a CiteScore percentile of at least 65 in Scopus. - Or at least 1 (one) article or review in a peer-reviewed scientific journal indexed in SCIE (Web of Science) and included in the 1st (first) quartile by impact factor in Web of Science and/or with a CiteScore percentile of at least 80 in Scopus.