The aim of the project: The aim of our study was the clinical and genetic assessment of the risk of cardiovascular disease in athletes of the national teams of the Republic of Kazakhstan for Olympic sports.
Expected Results: As part of this study, we will carry out a clinical and genetic assessment of the risk of cardiovascular disease in athletes of national teams of the Republic of Kazakhstan in Olympic sports. On the basis of assessment of clinical and functional state of cardiovascular system of athletes of national teams of the Republic of Kazakhstan on Olympic sports we will form a sample of active athletes, representing priority sports, related to those disciplines, which require large amounts of oxygen and give the greatest load on the cardiovascular system. Screening of genes and their variants associated with cardiovascular disease will be performed using the HaloPlex cardiogenetic panel we have developed. Based on these data we will search for associations between mutations in the studied genes and the risk of cardiovascular disease in athletes of the national teams of the Republic of Kazakhstan in Olympic sports.
Relevance: This project focuses on the risk of cardiovascular disease (CVD) in athletes. Sudden cardiac death is the most common cause of death in athletes participating in sports. A number of underlying structural, arrhythmic, and inherited cardiovascular diseases (ICVDs) can increase an athlete's risk of sudden cardiac death while playing sports. However, the athlete's heart undergoes physiological adaptations such as QT interval prolongation, left ventricular hypertrophy, and cavity dilatation that result from high athletic activity and can be recognized as physiological cardiac adaptations. Screening genetic variants of genes associated with cardiovascular disease using a cardiogenetic panel will help to provide a clearer assessment of the clinical and functional state of the cardiovascular system in athletes.
Expected Results: As part of this study, we will carry out a clinical and genetic assessment of the risk of cardiovascular disease in athletes of national teams of the Republic of Kazakhstan in Olympic sports. On the basis of assessment of clinical and functional state of cardiovascular system of athletes of national teams of the Republic of Kazakhstan on Olympic sports we will form a sample of active athletes, representing priority sports, related to those disciplines, which require large amounts of oxygen and give the greatest load on the cardiovascular system. Screening of genes and their variants associated with cardiovascular disease will be performed using the HaloPlex cardiogenetic panel we have developed. Based on these data we will search for associations between mutations in the studied genes and the risk of cardiovascular disease in athletes of the national teams of the Republic of Kazakhstan in Olympic sports.
Relevance: This project focuses on the risk of cardiovascular disease (CVD) in athletes. Sudden cardiac death is the most common cause of death in athletes participating in sports. A number of underlying structural, arrhythmic, and inherited cardiovascular diseases (ICVDs) can increase an athlete's risk of sudden cardiac death while playing sports. However, the athlete's heart undergoes physiological adaptations such as QT interval prolongation, left ventricular hypertrophy, and cavity dilatation that result from high athletic activity and can be recognized as physiological cardiac adaptations. Screening genetic variants of genes associated with cardiovascular disease using a cardiogenetic panel will help to provide a clearer assessment of the clinical and functional state of the cardiovascular system in athletes.