Conference Program

Day 1: Wednesday, September 17
Venue: Ballroom Right, Block C2, Nazarbayev University
08:00 – 08:30
Registration
08:30 – 09:00
Welcome & Introduction
Welcome & Introduction by Dos Sarbassov
Director General of National Laboratory Astana
Welcome note by Ahmad Waqar
President of Nazarbayev University
Welcome note by Zhaxybay Zhumadilov 
Founder of CLS
Welcome note by Almaz Sharman
Founder of CLS
Welcome note by Rakhmetkazhi Bersimbay
Professor at the Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Director of the Institute of Cell Biology and Biotechnology
09:00 - 09:20
Professor Dos Sarbassov, Director General of the National Laboratory Astana, Kazakhstan
Title: Celebrating 15 Years of Innovation at the Center for Life Sciences: From Discovery to the Bedside
09:20 - 09:40
Professor Almaz Sharman, President of the Academy of Preventive Medicine, Kazakhstan
Title: Technologies Shaping Quality Longevity
09:40 - 10:00
Professor Yuriy Pya, Chairman of the Board of the "University Medical Center" Corporate Fund, Astana, Kazakhstan
Title: TBA
10:00 - 10:30
Keynote speech
Professor Bart Loeys, Antwerp University Hospital/University Hospital, Antwerp, Belgium and Radboud University Medical Center, Nijmegen, The Netherlands
Title: New insights from hereditary aortopathies
10:30 - 11:00
Coffee Break
SESSION 1 - GENOMIC AND PERSONALIZED MEDICINE
SESSION CHAIRS: Prof. Ainur Akilzhanova & Prof. Joseph D.Terwilliger

Venue: Ballroom Right, Block C2, Nazarbayev University

11:00 - 11:25
Keynote speech
Professor Joseph D.Terwilliger, Geneticist and professor of neurobiology at the Columbia University Medical Center and the New York State Psychiatric Institute, USA
Title: Polygenic Fortune Telling in the Era of Precision Medicine: A Case Study in Predictive Failure
11:25 - 11:45
Professor Vladimir Saenko, Associate Professor, Department of Radiation-Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Graduate School of Medical Sciences, Nagasaki University, Japan
Title: Contribution of genetic variants and environmental exposure to thyroid cancer
11:45 - 12:05
Professor Ainur Akilzhanova, Director of the Center for Life Sciences, National Laboratory Astana, Kazakhstan
Title: Genomic studies at Center for Life Sciences- paving the way for personalized medicine in Kazakhstan
12:05 - 12:25
Dr Richard Carter, Chief Scientific Officer, Legion BioSolutions
Title: Data Considerations in Biotechnology
12:25 - 12:40
Professor Ulykbek Kairov, Head of the Laboratory of bioinformatics and systems biology, Center for Life Sciences, National Laboratory Astana, Kazakhstan
Title: TBA
12:40 - 12:55
Professor Makhabbat Bekbossynova, Deputy Chairman of the Board of the Corporate Fund “University Medical Center” (UMC), President of the Public Association “Kazakhstan Society of Atherosclerosis,” Chief Freelance Cardiologist of the Ministry of Health of the Republic of Kazakhstan, Astana, Kazakhstan
Title: Genetic predisposition to atherosclerosis and dyslipidemia: Kazakhstani study
12:55 - 13:10
Dr Krzysztof Borkowski, Microscopic imaging systems specialist,
Evident Scientific
Title: EVIDENT confocal systems: new horizons in microscopic imaging
13:10-14:15
LUNCH
13:10-14:15
POSTER SESSION
Venue: Upper atrium
SESSION 2 - CANCER BIOLOGY
SESSION CHAIRS: Prof. Yasemin Sancak & Prof. Nikolai Barlev
Venue: Ballroom Right, Block C2, Nazarbayev University
14:15 - 14:40
Keynote speech
Professor Gerry Melino, Director of Centre of Excellence “Torvergata Oncoscience Research”, University of Rome Tor Vergata, Italy
Title: The Complexity of Quality Control, or the p53 family
14:40 - 15:05
Keynote speech
Professor Mauro Piacentini, University of Rome Tor Vergata, Italy
Title: Transglutaminase type 2 Inhibition prevents hepatocellular carcinoma development by metabolic reprogramming.
15:05 - 15:25
Professor Yasemin Sancak, Associate Professor, Department of Pharmacology, University of Washington, USA
Title: Mitochondrial Calcium Signaling in the Pediatric Liver Cancer FLC
15:25 - 15:45
Professor Eugene Tulchinsky, School of Medicine, Nazarbaye University, Kazakhstan
Title: Epithelial-mesenchymal transition in bladder cancer: The impact of mRNA alternative splicing
15:45 - 16:05
Professor Nikolai Barlev, School of Medicine, Nazarbaye University, Kazakhstan
Title: Molecular mechanisms of solid tumor resistance to CAR-T therapy
16:05 - 16:20
Jerome Cabeau, Business Development Manager, Cell Therapy Solutions, Thermo Fisher Scientific, France
Title: One-day CAR-T cell manufacturing: from concept to practice
16:20 - 16:50

Coffee Break

SESSION 3 - Microbial Communities and Immune Responses
SESSION CHAIRS: Prof. Almagul Kushugulova & Dr Mo Han
Venue: Ballroom Right, Block C2, Nazarbayev University
16:50 - 17:10
Professor Almagul Kushugulova, Head of the Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Kazakhstan
Title: TBA
17:10 - 17:35
Keynote speech
Professor Hans-Uwe Simon, President of the Brandenburg Medical School, University of Bern, Switzerland
Title: Neutrophils and extracellular DNA traps
17:35 - 17:55
Dr. Mo Han, Institute of Digital Earth, BGI Research (Shenzhen/Sanya), China
Title: Beyond the Obvious: The Understudied Microbiome in Extreme Environments and Its Impact on Planetary and Human Health
17:55 - 18:15
Dr Lucas Moitinho Silva, Institute for Clinical and Molecular Biology & Institute of Experimental Medicine, Kiel University, Germany
Tile: Multi-omics exploration of the human gut microbiome in the context of industrialization
18:15 - 18:35
Professor Morenko Marina, Medical University Astana, Kazakhstan
Title: Neonatal microbiome and the establishment of immune tolerance
18:35 - 18:50
Professor Natalya Latypova, Director of Research Institute of Respiratory Medicine of NJSC "Medical University Astana" Kazakhstan
Title: Burden of lung diseases in Kazakhstan: reality and prospects
18:50 - 19:00
Group photo
19:00 - 21:00
WELCOME RECEPTION
Venue: Upper atrium
Day 2: Thursday, September 18
Venue: Ballroom Right, Block C2, Nazarbayev University
SESSION 4 - PHYSIOLOGY AND METABOLISM
SESSION CHAIR: Professor David A. Guertin & Professor Talgat Nurgozhin
08:30 - 08:55
Keynote speech
Professor David A. Guertin, Institute of Organic Chemistry and Biochemistry of the CAS, USA
Title: Targeting Nutrient Sensing Pathways to Combat Obesity and Metabolic Diseases
08:55 - 09:15
Professor Raushan Kurmasheva, Director, CPRIT Core,
Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health at San Antonio, USA
Title: Exploiting DNA Repair Vulnerabilities in Pediatric Solid Tumors: Dual Targeting of PARP1 and Alkylation Damage Response
09:15 - 09:35
Professor Svetlana V. Mankovskaya, Vice-Director of scientific and innovative work , Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus
Title: Experimental models in vivo are the basis of translational medicine
09:35 - 09:55
Professor Murat Saparbayev, Université Paris-Saclay, CNRS UMR9019 - Group «Mechanisms of DNA Repair and Carcinogenesis», Gustave Roussy Cancer Campus, France
Title: Repair of 5-hydroxymethylcytosine residues in DNA and its possible biological role
09:55 - 10:15
Professor Talgat Nurgozhin, Doctor of Medical Sciences, Professor, Academician of the National Academy of Sciences of the Republic of Kazakhstan
Title: Функциональное питание и нутритивные вмешательства в профилактике и терапии деменции
10:15 - 10:35
Professor Eugene Ponomarev, School of Science and Humanities, Nazarbayev University, Kazakhstan
Title: Metabolic Reprogramming of Macrophages Towards Regenerative Phenotype
10:35 - 11:10
Coffee Break
SESSION 5 - REGENERATIVE MEDICINE and BIOENGINEERING
SESSION CHAIR: Professor Julietta V. Rau & Professor Yuliya Safarova
11:10 - 11:35
Keynote Speech
Professor Julietta V. Rau, Associate Research Director at the Institute of the Structure of Matter of Italian National Research Council, Italy
Title: Emerging Biomaterials in Biomedicine: Antimicrobial, Bioactive, and Implantable Solutions
11:35 - 11:55
Professor Prim Singh, School of Medicine, Nazarbaye University, Kazakhstan
Title: Age reprogramming: cell rejuvenation by partial reprogramming
11:55 - 12:15
Professor Johannes de Munter, University of Maastricht, Netherlands
Title: The challenges of performing a phase I and Phase II study with an autologous stem cell product Neuro-Cells® to combat neurodegeneration
12:15 - 12:35
Professor Vyacheslav Ogai, National Center of Biotechnology, Kazakhstan
Title: Hydrogel-Based Delivery System for Regeneration of Articular Cartilage Defects
12:35 - 12:45
Professor Maaike Alaerts, University of Antwerp, Netherlands
Title: iPSC-Derived Cardiomyocytes as a Tool for Precision Medicine in Inherited Cardiac Arrhythmia
12:45 - 13:05
Professor Vesselin Paunov, School of Sciences and Humanities, Nazarbayev University, Kazakhstan
Title: TBA
13:05 - 13:25
Professor Gorka Orive, Full Professor of Pharmacy and Pharmaceutical Technology Institution: University of the Basque Country, Vitoria-Gasteiz, Spain
Title: A Scientific Journey:From Regenerative Medicine to Diagnostics and Health Sustainability
13:25 – 14:25
POSTER SESSION
Venue: Upper atrium
SESSION 6 - NEURODEGENERATIVE RESEARCH
SESSION CHAIR: Professor Daniel C. Anthony & Professor Sholpan Askarova
14:25 – 14:50
Keynote speech
Professor Daniel C. Anthony, Professor of Experimental Neuropathology, University of Oxford, UK
Title: From Liver to Limbic System: How Peripheral Disease Shapes Brain Health
14:50 – 15:15
Keynote speech
Professor Joseph H. Lee, Professor of Epidemiology, Neurology
Sergievsky Center,  Columbia University Irving Medical Center, Taub Institute, Department of Epidemiology, USA
Title: Integrative Study of Alzheimer's Disease via Extreme Sampling: From Neurology to Genetic Epidemiology to Functional Genetics
15:15 – 15:35
Professor Tatyana Strekalova, Graduate School of Life Sciences of University of Wuerzburg, Germany
Title: A new mouse model of amyotrophic lateral sclerosis with fus gene mutation: mechanisms of neuropathology and effects of standard and new treatments
15:35 – 15:55
Professor Dieter Riethmacher, School of Medicine, Nazarbaye University, Kazakhstan
Title: Is the matricellular protein Periostin involved in peripheral nerve regeneration?
15:55 – 16:25
Coffee Break
16:25 – 16:45
Professor Leyla Djansugurova, Institute of Genetics and Physiology, Almaty, Kazakhstan
Title: Analysis of cognitive functions and neurodegenerative diseases selection signals in Central Eurasian population through time
16:45 – 17:00
Dr Zhibek Zholdasova, Universal Brain Center, Almaty, Kazakhstan
Title: Two-faced Janus of longevity. Dementia. Kazakhstan - pros and cons
17:00 – 17:20
Professor Nazira Zharkinbayeva, Head of the Department of Neurology, Psychiatry, Rehabilitation, and Neurosurgery, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Title: Клинико-демографическая характеристика болезни Паркинсона в южном регионе Казахстана
17:20 – 17:40
TBA
17:40 – 18:00
Professor Sholpan Askarova, Head of the Laboratory of Bioengineering and Regenerative Medicine, Center for Life Sciences, National Laboratory Astana, Kazakhstan
Title: Comprehensive Profiling of Alzheimer's Disease in Kazakhstan: Clinical, Genetic, and Microbiome Insights
Day 3: Friday, September 19
Venue: Ballroom Right, Block C2, Nazarbayev University
09:00 - 09:25
Keynote speech
Professor Thomas Jentsch, Professor, Leader of Research Unit ‘Physiology and Pathology of Ion Transport’ Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Germany
Title: Anion transport across biological membranes: physiology and disease
09:25 - 10:35
Oral talks - YOUNG SCIENTIST COMPETITION
09:25 - 09:35
Kuanysh Dossybayeva, Nazarbayev University School of Medicine, Kazakhstan
Title: Analysis of T cell subpopulations by flow cytometry in patients affected with immune-mediated disorders
09:35 - 09:45
TBA
Title:
09:45 - 09:55
TBA
Title:
09:55 - 10:05
TBA
Title:
10:05 - 10:15
TBA
Title:
10:15 - 10:25
TBA
Title:
10:25 - 10:35
TBA
Title:
10:35 - 11:00
Coffee break
11:00 - 12:00
POSTER SESSION
12:00 - 12:30
Award Ceremony – Best Oral Presentation, Best Poster Presentation
12:30 - 12:45
Conference closing remarks
12:45 - 13:30
ADVISORY BOARD
13:30 - 14:30
LUNCH
14:30 - 17:30
Astana Bus City Tour (for speakers)