Laboratory of Bioengineering and Regenerative Medicine

Expertise and Equipment



Analysis of cell proliferation and cell cycle

Muse® Cell Analyzer/MERCK 

Electrochemiluminescence immunoassay method for proteins detection in cell cultures, tissues and other biological samples

Multiplex imager MSD QuickPlex SQ 120

Production of luciferase expressing cell lines


Quantitative fluorescent microscopy  

Inverted fluorescent microscope  Olympus IX83

In-vivo fluorescent and bioluminescent tomography

IVIS Spectrum CT/Caliper

In-vivo micro-CT

IVIS Spectrum CT/Caliper

In-vivo rat model of estrogen-depended osteoporosis

ØAnesthesia system

ØAnimal surgery room

ØSmall animal facility

In-vivo rat model of bone fracture

In-vivo rat model of ischemic stroke

Lyophilic drying


Gel electrophoresis, Western blot, PCR

ChemiDoc MP Bio-Rad

Quantitative spectrophotometry

Hybrid reader Synergy H1

Selected peer-reviewed  publications

  • Yuliya Safarova (Yantsen), Farkhad Olzhayev, Bauyrzhan Umbayev, Andrey Tsoy, Gonzalo Hortelano,Tursonjan Tokay, Hironobu Murata, Alan Russell and Sholpan Askarova. Mesenchymal Stem Cells Coated with Synthetic Bone-Targeting Polymers Enhance Osteoporotic Bone Fracture Regeneration // Bioengineering 2020, 7(4), 125;
  • Ogay Vyacheslav, Kumasheva Venera, Li Yelena, Mukhlis Sholpan, Sekenova Aliya, Olzhayev Farkhad, Tsoy Andrey, Umbayev Baurzhan, Askarova Sholpan, Shpekov Azat, Kaliyev Assylbek, Zhetpisbayev Berik, Makhambetov Yerbol, Saparov Arman, Akshulakov Serik, Ramankulov Yerlan. Improvement of Neurological Function in Rats with Ischemic Stroke by Adipose-Derived Pericytes // Cell Transplantation, 2020,
  • BauyrzhanUmbayev, Sholpan Askarova, Aigul Almabayeva, TimurSaliev, Abdul-Razak Masoud, Denis Bulanin. Galactose-induced skin aging: The role of oxidative stress. // Oxidative Medicine and Cellular longevity. Volume 2020 |Article ID 7145656, 15 pages,
  • Safarova Y , Umbayev B, Hortelano G3, Askarova Sh. Mesenchymal stem cells modifications for enhanced bone targeting and bone regeneration // Regenerative Medicine. 2020, 15(4), pp.1579-1594
  • Sholpan Askarova, Bauyrzhan Umbayev, Abdul-Razak Masoud, Aiym Kaiyrlykyzy, Yuliya Safarova, Andrey Tsoy, Farkhad Olzhayev, Almagul Kushugulova. The links between the gut microbiome, aging, modern lifestyle and Alzheimer’s disease // Front. Cell. Infect. Microbiol., 18 March 2020,
  • Andrey Tsoy, Timur Saliev, Elvira Abzhanova, Anel Turgambayeva, Aiym Kaiyrlykyzy, Mars Akishev, Samat Saparbayev and Sholpan Askarova. The effects of mobile phone radiofrequency electromagnetic fields on induced by β-amyloid and H2O2 oxidative stress and activation of MAPKs in human and rat primary astrocytes // Neuroscience (2019); 408:46-57
  • Tao Teng, Devin Ridgley, Andrey Tsoy, Grace Sun, Sholpan Askarova, James Lee. Azelnidipine attenuates the oxidative pathway and NFκB activations in amyloid-β-stimulated cerebral endothelial cells // ACS Chemical Neuroscience. 2019; 10(1):209-215.
  • Dauren Alimbetov, Sholpan Askarova, Bauyrzhan Umbayev, Terence Davis and David Kipling. Pharmacological Targeting of Cell Cycle, Apoptotic and Cell Adhesion Signaling Pathways Implicated in Chemoresistance of Cancer Cells//Int. J. Mol. Sci.(2018)19(6), 1690; 
  • Bauyrzhan Umbayev, Masoud Abdul-Razak, Andrey Tsoy, Dauren Alimbetov, Farkhad Olzhayev, Aiym Kaiyrlykyzy, Yulia Safarova, Terence Davis and Sholpan Askarova. Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells // Biogerontology(2018), 19:287-301
  • Akilbekova D, Ogay V, Yakupov T, Sarsenova M, Umbayev B, Nurakhmetov A, Tazhin K, Yakovlev VV, Utegulov ZN. Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones//J Biomed Opt. 2018 Sep;23(9):1-11. doi: 10.1117/1.JBO.23.9.097004.

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